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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 1
2002 4
2003 28
2004 43
2005 30
2006 30
2007 34
2008 36
2009 46
2010 59
2011 35
2012 50
2013 47
2014 42
2015 26
2016 31
2017 35
2018 31
2019 30
2020 31
2021 36
2022 29
2023 24
2024 3

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674 results

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Page 1
DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagy.
Imberechts D, Kinnart I, Wauters F, Terbeek J, Manders L, Wierda K, Eggermont K, Madeiro RF, Sue C, Verfaillie C, Vandenberghe W. Imberechts D, et al. Brain. 2022 Dec 19;145(12):4368-4384. doi: 10.1093/brain/awac313. Brain. 2022. PMID: 36039535 Free PMC article.
Loss-of-function mutations in the PRKN, PINK1 and PARK7 genes (encoding parkin, PINK1 and DJ-1, respectively) cause autosomal recessive forms of Parkinson's disease. ...Here, we investigated PINK1/parkin-mediated mitophagy in cultured human fibroblasts and induced pluripot …
Loss-of-function mutations in the PRKN, PINK1 and PARK7 genes (encoding parkin, PINK1 and DJ-1, respectively) cause autosomal recessi …
The cell biology of Parkinson's disease.
Panicker N, Ge P, Dawson VL, Dawson TM. Panicker N, et al. J Cell Biol. 2021 Apr 5;220(4):e202012095. doi: 10.1083/jcb.202012095. J Cell Biol. 2021. PMID: 33749710 Free PMC article. Review.
Parkinson's disease protein PARK7 prevents metabolite and protein damage caused by a glycolytic metabolite.
Heremans IP, Caligiore F, Gerin I, Bury M, Lutz M, Graff J, Stroobant V, Vertommen D, Teleman AA, Van Schaftingen E, Bommer GT. Heremans IP, et al. Proc Natl Acad Sci U S A. 2022 Jan 25;119(4):e2111338119. doi: 10.1073/pnas.2111338119. Proc Natl Acad Sci U S A. 2022. PMID: 35046029 Free PMC article.
Here we report that PARK7, an enzyme mutated in hereditary Parkinson's disease, prevents damage of proteins and metabolites caused by a metabolite of glycolysis. ...Our work demonstrates that PARK7 function represents a highly conserved strategy to prevent damage in …
Here we report that PARK7, an enzyme mutated in hereditary Parkinson's disease, prevents damage of proteins and metabolites caused by …
Identification of exosomal biomarkers and its optimal isolation and detection method for the diagnosis of Parkinson's disease: A systematic review and meta-analysis.
Nila IS, Sumsuzzman DM, Khan ZA, Jung JH, Kazema AS, Kim SJ, Hong Y. Nila IS, et al. Ageing Res Rev. 2022 Dec;82:101764. doi: 10.1016/j.arr.2022.101764. Epub 2022 Oct 20. Ageing Res Rev. 2022. PMID: 36273807 Review.
However, this diagnosis method is not accurate due to overlapping criteria of other neurodegenerative diseases. Exosomes are differentially expressed in PD and a combination of types and contents of exosomes might be used as a biomarker in PD. ...Exosomal alpha-synuclein ( …
However, this diagnosis method is not accurate due to overlapping criteria of other neurodegenerative diseases. Exosomes are differen …
PARK7/DJ-1 in microglia: implications in Parkinson's disease and relevance as a therapeutic target.
Lind-Holm Mogensen F, Scafidi A, Poli A, Michelucci A. Lind-Holm Mogensen F, et al. J Neuroinflammation. 2023 Apr 18;20(1):95. doi: 10.1186/s12974-023-02776-z. J Neuroinflammation. 2023. PMID: 37072827 Free PMC article. Review.
Microglia are the immune effector cells of the brain playing critical roles in immune surveillance and neuroprotection in healthy conditions, while they can sustain neuroinflammatory and neurotoxic processes in neurodegenerative diseases, including Parkinson's disease (PD) …
Microglia are the immune effector cells of the brain playing critical roles in immune surveillance and neuroprotection in healthy conditions …
PARK7/DJ-1 as a Therapeutic Target in Gut-Brain Axis Diseases.
Pap D, Veres-Székely A, Szebeni B, Vannay Á. Pap D, et al. Int J Mol Sci. 2022 Jun 14;23(12):6626. doi: 10.3390/ijms23126626. Int J Mol Sci. 2022. PMID: 35743072 Free PMC article. Review.
All these findings suggest that PARK7/DJ-1 may be a link and also a potential therapeutic target in gut and brain diseases. In this review, therefore, we discuss our current knowledge about PARK7/DJ-1 in the context of GBA diseases....
All these findings suggest that PARK7/DJ-1 may be a link and also a potential therapeutic target in gut and brain diseases. In …
DJ-1 in neurodegenerative diseases: Pathogenesis and clinical application.
Huang M, Chen S. Huang M, et al. Prog Neurobiol. 2021 Sep;204:102114. doi: 10.1016/j.pneurobio.2021.102114. Epub 2021 Jun 24. Prog Neurobiol. 2021. PMID: 34174373 Free article. Review.
Neurodegenerative diseases (NDs) are one of the major health threats to human characterized by selective and progressive neuronal loss. ...PARK7 mutations, altered expression and posttranslational modification (PTM) cause DJ-1 abnormalities, which in turn lead to do …
Neurodegenerative diseases (NDs) are one of the major health threats to human characterized by selective and progressive neuronal los …
Role of PARK7 and NDKA in stroke management: a review of PARK7 and NDKA as stroke biomarkers.
Mingina T, Zhao M. Mingina T, et al. Biomark Med. 2018 May;12(5):419-425. doi: 10.2217/bmm-2018-0013. Epub 2018 Apr 26. Biomark Med. 2018. PMID: 29697269 Review.
AIM: Biomarkers are molecules measured in plasma, serum or other body fluids to characterize a disease. PARK7 and NDKA roles in the management of stroke are still on study. ...CONCLUSION: This article explores recent findings and proposes the potential roles that PARK7 …
AIM: Biomarkers are molecules measured in plasma, serum or other body fluids to characterize a disease. PARK7 and NDKA roles in the m …
PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains T(reg) homeostasis during ageing.
Danileviciute E, Zeng N, Capelle CM, Paczia N, Gillespie MA, Kurniawan H, Benzarti M, Merz MP, Coowar D, Fritah S, Vogt Weisenhorn DM, Gomez Giro G, Grusdat M, Baron A, Guerin C, Franchina DG, Léonard C, Domingues O, Delhalle S, Wurst W, Turner JD, Schwamborn JC, Meiser J, Krüger R, Ranish J, Brenner D, Linster CL, Balling R, Ollert M, Hefeng FQ. Danileviciute E, et al. Nat Metab. 2022 May;4(5):589-607. doi: 10.1038/s42255-022-00576-y. Epub 2022 May 26. Nat Metab. 2022. PMID: 35618940
Pyruvate dehydrogenase (PDH) is the gatekeeper enzyme of the tricarboxylic acid (TCA) cycle. Here we show that the deglycase DJ-1 (encoded by PARK7, a key familial Parkinson's disease gene) is a pacemaker regulating PDH activity in CD4(+) regulatory T cells (T(reg) cells). …
Pyruvate dehydrogenase (PDH) is the gatekeeper enzyme of the tricarboxylic acid (TCA) cycle. Here we show that the deglycase DJ-1 (encoded b …
674 results